Kanna
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This scientific research is for informational use only. The results reported may not necessarily occur in all individuals. Care/of provides this information as a service. This information should not be read to recommend or endorse any specific products.
The succulent herb kanna is indigenous to South-Africa and was used for centuries by the indigenous hunter-gatherer San people to support cognitive focus and memory. Scientific research on Kanna is emerging, but more is needed to determine the herb’s impact on brain health.*
Cognitive Support
In a randomized placebo-controlled cross-over study, 21 human subjects took 25 mg Sceletium tortuosum (Kanna) extract or placebo once daily / 9 weeks. Kanna-treated subjects and placebo-treated subjects were administered the CNS Vital SignR battery of neuropsychological tests at baseline and at the end of the treatment period. Cognitive domains were derived from CNS Vital SignR tests. Kanna significantly improved cognitive flexibility, and executive function as compared with placebo. More studies should be performed to confirm and expand the results of this study.1
In a double-Blind, randomized, placebo-controlled, 3-Armed study with parallel design 60 healthy adult subjects took a single dose (25 mg) Sceletium tortuosum (Kanna) extract or placebo. A 17-channel EEG recording was combined with Eye-Tracking before dose intake, and again 120 minutes following intake. In comparison to placebo, Kanna induced enhanced increases in power of frontal delta, theta, alpha1 and alpha2 frequencies during several tasks. Since increases in these frequencies in the frontal brain have been related to attention and memory, these results may represent a positive action on cognitive actions in the brain. More studies should be performed to confirm and expand the results of this study.2
References
Proof-of-Concept Randomized Controlled Study of Cognition Effects of (a) Proprietary Extract (of) Sceletium tortuosum Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects
Chiu S, Gericke N, Evidence-Based Complementary and Alternative Medicine, 2014
Psychophysiological Effects of (Proprietary Extract of Sceletium tortuosum) Using Quantitative EEG Source Density in Combination with Eye-Tracking in 60 Healthy Subjects. A Double-Blind, Randomized, Placebo-Controlled,3-Armed Study with Parallel Design.
Dimpfel W, Gericke N, Neuroscience and Medicine, 2016
Mood
In a randomized placebo-controlled cross-over study, 21 human subjects took 25 mg Sceletium tortuosum (Kanna) extract or placebo once daily for 9 weeks. Kanna-treated subjects and placebo-treated subjects were administered battery of neuropsychological tests, including CNS Vital Signs and Hamilton depression rating scale (HAM-D) at baseline and regular intervals. Kanna-treated subjects reported a larger decrease in HAM-D scores when compared to the placebo-treated group. More studies should be performed to confirm and expand the results of this study.1
References
Proof-of-Concept Randomized Controlled Study of Cognition Effects of (a) Proprietary Extract (of) Sceletium tortuosum Targeting Phosphodiesterase-4 in Cognitively Healthy Subjects
Chiu S, Gericke N, Evidence-Based Complementary and Alternative Medicine, 2014